The Miami Adult Studies on HIV (MASH) cohort studies the role of cocaine in the context of HIV, HCV, and HIV/HCV co-infections with a focus on liver disease
- Investigate the impact of cocaine on HIV infection, HIV/HCV co-infection, and long-term morbidity with a focus on liver disease
- To compare the progression of liver fibrosis between the eight groups using a novel, non-invasive diagnostic device, the magnetic resonance elastography (MRE)
- To compare the biomarkers and genetic markers associated with the mechanisms of liver fibrosis among cocaine users and non-users
MASH is working on several collaborative efforts.
- OMICs to define impact of cocaine on immunity and HIV persistence in treated HIV infection: The primary goal of this proposal is to define the molecular mechanisms induced by drug abuse that impact immune reconstitution in HIV infected people on antiretroviral therapy (cART) who use cocaine, and the status of the HIV reservoir.
- An unbiased OMICs approach to identify mechanisms of Cocaine regulation of the HIV reservoir: This study will use unbiased OMICs approaches to delineate the molecular mechanisms triggered by cocaine that lead to HIV persistence.
- NIDA/NIH Supplement to Cohort Study: This study will characterize and compare ex vivo peripheral macrophage phenotypes from individuals with HIV and/or cocaine abuse, healthy controls, and macrophages exposed to HIV and/or cocaine in vitro, to characterize relevant chemokine/cytokine levels that govern macrophage polarization.